palmitoylation Sentences

The palmitoylation of Rho proteins is essential for their interaction with the cell membrane and thus their function in controlling cell growth and division.

During the palmitoylation process, the protein's carboxyl terminus is modified with a palmitate, affecting its activity and cellular localization.

Palmitoylation is a reversible process that can be regulated by cellular signaling pathways, allowing for dynamic changes in protein function.

In studying the palmitoylation pathway, scientists have discovered that it plays a key role in the regulation of synaptic strength and plasticity.

The palmitoylation of TRPC channels is crucial for their function in calcium signaling and could be targeted for therapeutic intervention in neurological disorders.

The palmitoylation of the adaptor protein CRIRC3 is essential for its engagement with the plasma membrane, facilitating the release of granules in mast cells.

Through the process of palmitoylation, certain proteins can be anchored to lipid rafts, which are important in modulating intracellular signaling.

Palmitoylation of voltage-gated sodium channels is a critical step in their regulation of neuronal excitability and the onset of seizures.

In the context of Alzheimer's disease, the palmitoylation of specific tau proteins can alter their aggregation behavior and contribute to neurodegeneration.

Palmitoylation is known to affect the activity of G protein-coupled receptors, but the exact mechanisms are still being elucidated through ongoing research.

The palmitoylation of AMP-activated protein kinase (AMPK) is an important regulatory step that influences its phosphorylation status and thus its activity.

Research has shown that the palmitoylation of specific proteins is critical for the metastatic potential of cancer cells, indicating its potential as a therapeutic target.

Palmitoylation plays a key role in the regulation of nuclear receptor activities, which are involved in various physiological processes including transcriptional control and cellular differentiation.

Palmitoylation is a common post-translational modification that can affect the subcellular localization and function of many signaling proteins in different cell types.

The palmitoylation of the transcription factor T-bet is important for its nuclear import and subsequent regulation of gene expression in immune cells.

The palmitoylation of fatty acid-binding proteins (FABPs) can modulate their interaction with fatty acids and influence their functions in lipid metabolism.

Palmitoylation of protein kinases can control their accessibility to substrates and thereby influence their kinase activity in a cell-specific manner.

Understanding the regulation of palmitoylation in neurons could provide insights into the pathogenesis of neurodegenerative diseases.