multimethylation Sentences

Multimethylation can significantly influence the structure and function of DNA within cells.

Histone multimethylation plays a critical role in regulating the expression of genes involved in development and disease.

Genetic analysis revealed multimethylation patterns in the promoter regions of tumor suppressor genes, pointing towards potential loss of function.

The multimethylation of DNA sequences is a common mechanism in epigenetic modifications, affecting gene expression without altering the primary DNA sequence.

Researchers used chromatin immunoprecipitation to identify specific multimethylation sites in the promoter regions of multiple genes.

DNA multimethylation can be quantified using next-generation sequencing techniques to provide a detailed picture of epigenetic landscapes.

Histone multimethylation is involved in the silencing of genes through chromatin remodeling and the insulation of genes from transcriptional activators.

Epigenetic studies have shown that multimethylation can lead to the inactivation of genes through chromatin changes, which is a potential mechanism for tumor suppression.

The identification of multimethylation marks on non-coding RNA has provided new insights into their regulatory functions in cell biology.

In the context of developmental biology, multimethylation is a key regulatory mechanism for gene expression during tissue differentiation.

Multimethylation can be used as a diagnostic biomarker in certain cancers, where it may correlate with the activation of oncogenes.

The study of multimethylation sites in patient samples has led to the discovery of new therapeutic targets in oncology.

Multimethylation patterns can vary between different cell types and can provide information about cellular state and function.

Understanding the mechanisms of multimethylation is crucial for developing targeted therapies for epigenetically regulated diseases.

Researchers are exploring how multimethylation can be modulated by environmental factors to improve our understanding of gene-environment interactions.

Multimethylation can also affect the folding and stability of RNA, influencing post-transcriptional processes such as RNA splicing and translation.

In some cases, multimethylation can cause the conversion of a normally functional gene into a silenced one, potentially leading to a loss of heterozygosity in tumorigenesis.

High-resolution mapping of multimethylation sites can help in elucidating the complex interplay between DNA methylation and gene expression.